2022 SEEG - The Course
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The Fundamentals of SEEG Course
Stereoelectroencephalography (SEEG) is a method for determining whether a pharmaco-resistant epilepsy can be relieved by surgery. From a pre-surgical procedure that requires the understanding of seizure semiology through its correlation with brain electrical activity, SEEG has evolved over time into a comprehensive approach of the patient with epilepsy.
This approach encompasses the successive steps of patient management since outpatient clinic to the surgical operation when it is indicated. Its implementation in the clinical setting requires a gathering of multidisciplinary skills. An ideal SEEG team is formed when a common culture is shared beyond the individual competencies.
The Fundamentals of SEEG course was designed to explore the scientific and medical bases of SEEG through its essential disciplines and their relationship. Theoretical courses were illustrated by practical demonstrations and case reports. This educational course was offered in the Spring in New Orleans, LA, and in the Fall in San Antonio, TX in 2022.
The course was designed to teach the scientific and medical bases of SEEG through its essential disciplines and their relationship. Its main objectives are:
Describe the evolution in time of the presurgical methods leading to the current practice of SEEG;
Figure out the anatomical basis of electrode implantation, its referential system, and how it prepares rational planning to tailored resection or ablation;
Examine what is the nature of the SEEG signal, how the depth electrodes capture it, and how the dynamics of multiple cortical sites recording can be understood;
Explore the concept of the neural network, its applicability to the epileptogenic process, and the way it determines the emergence of clinical semiology;
Make clear the logical chain linking SEEG to anatomically preplanned surgery;
Discuss in-depth illustrative cases.
Course Objectives
Who is this course for
The fundamentals of SEEG course was a specialized training intended for neurology and neurosurgery epilepsy physicians that are at junior faculty or second year fellowship level. Non-medical healthcare professionals are not able to attend this course.
Topics
Stereotaxic Anatomy
Biophysics of the SEEG signal
What is a neural network?
Pathophysiology of “focal” seizures
Anatomo-Electro-Clinical Correlations
From Epileptogenic Zone to Clinical semiology
Electrical stimulation in SEEG
Anatomical design of epilepsy surgery
2022 SEEG - THE COURSE FACULTY
Thandar Aung MD, MS
Neurologist
University of Pittsburgh Medical Center
Thandar Aung MD, MS
Neurologist
University of Pittsburgh Medical Center
Dr. Aung is a board-certified neurologist with a subspecialty certification in epilepsy and clinical neurophysiology by the American Board of Psychiatry and Neurology. She graduated from the Institute of Medicine, Burma in 2008 and completed adult neurology residency training at Barrow Neurological Institute, Phoenix, Arizona. She did her postgraduate training in Epilepsy and Clinical Neurophysiology with an emphasis in surgical epilepsy and magnetoencephalography training at Cleveland Clinic.
Catherine Liegeois Chauvel, PhD
Catherine Liegeois Chauvel, PhD
After a PhD in Neurosciences at the University Pierre and Marie Curie-Paris VI (France), Catherine Liegeois Chauvel started as Charge de Recherches in the INSERM unit led by Jean Bancaud at Ste Anne Hospital in Paris in 1985. She was, the first, to describe the anatomo-physiology organization of the auditory cortex in Man. The intracerebral electrodes implanted in patients undergoing presurgical investigations for intractable epilepsy provided an unique opportunity to record in vivo the cortical responses. A functional asymmetry of the right and left auditory cortices has been demonstrated and a physiological index of speech perception underlying the hemispheric lateralization for language comprehension has been evidenced from the left auditory cortex.
Then, she pursued her carrier as Director de Recherche INSERM in Marseille. Her research was dedicated on the characterization of the spatio-temporal dynamics of language networks Director de Recherche Emeritus since September 2018, she has spent part of her research time at the Cleveland Clinic (2013-2020) and in the Language, Cognition and Brain Sciences Laboratory at the Queensland University of Technology lead by Pr G de Zubicaray, as Adjunct Professor (2017-)
She joins the Cortical Systems Laboratory at the University of Pittsburgh in February 2020 as a research scientist to pursue her research on the characterization of language networks and its interaction with memory networks
Specialized Areas of Interest
Auditory perception, speech production, verbal memory. Intracerebral electrophysiology.
Patrick Chauvel, MD
Professor
University of Pittsburgh Medical Center and Aix-Marseille University
Patrick Chauvel, MD
Professor
University of Pittsburgh Medical Center and Aix-Marseille University
After achieving his medical and scientific studies in Neurology and in Neuroscience, Dr. Chauvel became an INSERM researcher. At that time, he began his work in experimental and later clinical research into the mechanisms of the epilepsies. Under the mentorship of Talairach and Bancaud at Hospital Sainte-Anne/University René Descartes, Paris, he developed SEEG as a presurgical method in epilepsy surgery. His research work has been devoted to the pathophysiology of the epileptogenic zone, emergence of seizure clinical semiology, and cerebral cortex physiology.
He has promoted the concept of epileptogenic network over the classical epileptic focus idea and opened new vistas in markers of the epileptogenic zone and semiology of focal epilepsies. Taking over from Jean Bancaud, Dr. Chauvel served as the Director of the SEEG Unit in Hospital Sainte-Anne in Paris (1986-1990), then Professor and Chairman of Neurology in Rennes (1990-1997) where he configured a new type of Epilepsy Unit including research, then Professor and Chairman of Clinical Neurophysiology and Director of the INSERM Institute of Systems Neuroscience in Marseille (1997-2014).
In 2014, he relocated to the Epilepsy Center of the Cleveland Clinic in order to promote the development of presurgical investigation using SEEG in North America. He was appointed as Professor of Neurology at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. In Brisbane, as Honorary Professor at the University of Queensland, he guided developing SEEG-based epilepsy surgery and related research program.
He is currently Professor of Neurology at the University of Pittsburgh, and Professor Emeritus of Physiology at Aix-Marseille University.
He is the author of more than 250 original articles in international journals and is a member of several international Scientific and Medical Societies. He has been elected as a Member of the Royal Academy of Medicine in Belgium.
Daniel L Drane, PhD
Associate Professor
Emory University
Daniel L Drane, PhD
Associate Professor
Emory University
Dr. Drane is an Associate Professor in the Departments of Neurology and Pediatrics at Emory University, and maintains an Affiliate Associate Professor position at the University of Washington School of Medicine, serving as Epilepsy Neuropsychology Program Director from 2001-2007). He is on the executive board of the Emory Neuromodulation Technology Innovation Center (ENTICe), and is a Fellow in the National Academy of Neuropsychology, APA Division 40, and the American Neurological Association.
Primary research involves predicting and improving epilepsy surgery outcome, with an emphasis on mapping structure-function relationships of the temporal lobes. Dr. Drane’s work combines cognitive assessment, stereoelectroencephalography, and neuroimaging procedures (e.g., diffusion tractography, quantitative MRI analysis, functional imaging) to understand the interplay of neural networks underlying cognition (particularly declarative memory, language, and face/object recognition) and emotion.
He has received continuous research funding from the National Institutes of Health (NIH) and industry sponsors for more than 15 years. He is currently serving as the Core Lab Director for the acquisition and analysis of data for the first clinical trial of laser ablation for temporal lobe epilepsy surgery (SLATE Trial, Medtronic, Inc.). He is also co-Director of the Emory Treatment Program for Psychogenic Nonepileptic Seizures.
He has strong interest in test development, previously leading the Test Development Committee while serving on the board of directors of the American Academy of Clinical Neuropsychology. Dr. Drane is involved in the creation of novel test measures using videography and virtual reality, and is serving as a site PI and co-investigator on the National Neuropsychology Network, a novel organization committed to the same goals of modernizing the practice of neuropsychology.
Jorge Gonzalez-Martinez, MD, PhD
Professor
University of Pittsburgh Medical Center
Jorge Gonzalez-Martinez, MD, PhD
Professor
University of Pittsburgh Medical Center
Dr. Gonzalez-Martinez is a board-certified neurosurgeon subspecialized in epilepsy and functional neurosurgery. He is the director of the epilepsy and movement disorders surgery, Co-Director of the Epilepsy Center and Director of the Cortical Systems Laboratory at the University of Pittsburgh Medical Center.
Dr. Gonzalez is a world-renowned surgeon who have published more than 200 peer-reviewed articles and book chapters related to epilepsy surgery and methods of brain mapping for patients with medically intractable epilepsy and movement disorders. He has been serving the American Society of Stereotactic and Functional Neurosurgery in the capacity of member of the executive committee for the last 6 years, developing high relevant projects and topics related to the field of functional neurosurgery and epilepsy.
Dr. Gonzalez is a medical pioneer in novel surgical methods for treating medically refractory seizures such as stereo-electroencephalography, SEEG guided laser ablative procedures, neuromodulatory interventions and robotic guided surgeries, bringing for the first time innovative surgical interventions to the United States and other countries. His particular field of interest and academic drive is related to neuro-electrophysiology, intracranial signal processing and behavioral neuroscience studies.
Combined, the clinical and basic science efforts have been guiding his academic and clinical pathway for safer and more efficient methods for treating patients with severe seizures and abnormal movement disorders, promoting the improvement of symptoms, in combination with better functional and quality of life outcomes.
Lisa Gillinder, MD
Neurologist
Princess Alexandra and Mater Hospitals
Lisa Gillinder, MD
Neurologist
Princess Alexandra and Mater Hospitals
Dr. Gillinder (BaApSciMRT, MBBS, MPhil, FRACP) completed her undergraduate training in medical radiation technology at the Queensland University of Technology. She completed her medical degree at the University of Queensland and fulfilled her physician and neurology training at the Princess Alexandra Hospital in Brisbane. She completed her epilepsy fellowship at the Mater Advanced Epilepsy Unit and now has a joint appointment as neurologist / epileptologist at Princess Alexandra and Mater Hospitals.
Dr. Gillinder specializes in stereo-electroencephalography (SEEG) and the surgical management of epilepsy. She has a strong research focus and is the lead of the Mater epilepsy research program. Her clinical studies are centered around improving epilepsy diagnostics and her pivotal work is investigating a link between seizure semiology and autoimmunity. Her other clinical studies are directed towards identifying novel epilepsy biomarkers, investigating medication optimization for Video EEG evaluation, improving functional MRI capabilities for pre-surgical language assessment and optimizing neuropsychological language
Dr. Gillinder is also passionate about pre-clinical research, which began during the completion of her MPhil in MRI spectroscopy. She is now a fellow of the Mater Research Institute and Queensland Brain Institute where she works collaboratively with pre-clinical researchers. Her current work includes investigating the fundamental computations of human neurons and the study of hippocampal progenitor cells. Dr. Gillinder’s work was recently recognized by her receipt of the ASMR Clinician Researcher Award and the Women in Technology Rising Star Award.
Olesya Grinenko, MD, PhD
Neurology Resident
Mercy Health Saint Mary’s
Olesya Grinenko, MD, PhD
Neurology Resident
Mercy Health Saint Mary’s
Dr. Grinenko received her MD degree at the Moscow State University and PhD degree in Neuroscience at the Institute of Higher Nervous Activity and Neurophysiology. After finishing her residency, she joined the epilepsy surgery program at Burdenko Neurosurgery Institute. In 2014 she came to Cleveland Clinic Epilepsy Center as a research fellow and then as a clinical fellow. Her research was focused on the analysis of epileptogenic zone characteristics based on SEEG data. Most of her clinical work was focused on patients with pharmaco-resistant epilepsy who are undergoing SEEG evaluation and surgical treatment. She was mentoring clinical fellows in SEEG reading and interpretation and was one of the tutors at SEEG Brain Mapping Workshop that took place at Cleveland Clinic. Currently, she is a neurology resident at Mercy Health Saint Mary’s, and she is also supervising medical students as a clinical assistant professor of a Department Division of Clinical Neuroscience Institution College of Human Medicine at Michigan State University.
Karim Jerbi, PhD
Professor
University of Montreal
Karim Jerbi, PhD
Professor
University of Montreal
Dr. Jerbi is a professor at the Psychology department of the University of Montreal. He is Canada Research Chair in Computational Neuroscience and Cognitive Neuroimaging and heads UNIQUE, a Neuro-AI research center (Unifying Neuroscience and AI in Quebec). He obtained a PhD in Cognitive Neuroscience and Brain Imaging from the Pierre & Marie Curie University in Paris and a biomedical engineering degree from the University of Karlsruhe (Germany). His research lies at the crossroads between cognitive, computational and clinical neuroscience. The goal of his research is (1) to elucidate the role of neural oscillations and large-scale neural communication in cognition, and (2) to investigate brain network alterations in the case of psychiatric and neurological disorders. The multidisciplinary research conducted in his laboratory combines magnetoencephalography, scalp- and intracranial electroencephalography, with advanced signal processing and data analytics including machine learning. Several ongoing projects in his lab use electrophysiological brain recordings to examine large-scale brain network dynamics in a range of cognitive processes (goal-directed behavior, decision-making, memory, etc.) and across different states of consciousness (wakefulness, sleep, dreaming, anesthesia and psychedelic states). Dr Jerbi also has a keen interest in the convergence between brain science, creativity and art.
Ammar Kheder, MD
Assistant Professor
Emory University
Ammar Kheder, MD
Assistant Professor
Emory University
Dr. Kheder is an assistant professor of neurology and pediatrics at Emory University, with primary interest in epilepsy surgery and SEEG. He is currently the medical director of epilepsy at the Children’s Healthcare of Atlanta. After completion of training in medicine and neurology in England, he completed two years epilepsy and neurophysiology fellowship at Massachusetts General Hospital. This was followed by one-year advanced fellowship in SEEG and epilepsy surgery at Cleveland Clinic. His research and clinical interests include semiology, functional neuroanatomy and intracranial neurophysiology.
Outside work, he enjoys cooking, music, outdoors and travel.
Aileen McGonigal, MD, PhD, MRCP
Neurologist
Director of Epilepsy Unit, Mater Hospital and University of Queensland, Brisbane, Australia
Aileen McGonigal, MD, PhD, MRCP
Neurologist
Director of Epilepsy Unit, Mater Hospital and University of Queensland, Brisbane, Australia
Dr. McGonigal is a neurologist with extensive specialist experience in epileptology and EEG, including stereo-EEG. Following UK neurology training, Prof McGonigal spent around 20 years in France where she studied and practised stereo-EEG methodology, contributing to its evolution through clinical research. Her research interests include seizure semiology and its neural correlates, and she has written and lectured widely on these. She took up her current post in Australia in 2022, and continues to develop use of stereo-EEG with an associated clinical research programme.
Guy McKhann, MD
Professor
Columbia University Irving Medical Center
Guy McKhann, MD
Professor
Columbia University Irving Medical Center
Dr. McKhann is the Director of Epilepsy Surgery, Brain Mapping for Tumors and Epilepsy, and Adult Hydrocephalus at Columbia University Irving Medical Center/New York Presbyterian Hospital. He has over 20 years of experience at CUIMC/NYP, combining clinical skill and compassionate care to maximize patient outcomes. He is a member of both the Columbia P&S Virginia Apgar Academy of Medical Educators and the P&S Academy of Clinical Excellence. His areas of particular technical expertise include awake brain mapping; epilepsy surgery; low grade glioma surgery; minimally invasive, computer guided microneurosurgery; and stereotactic laser ablation for tumors and epilepsy.
Dr. McKhann also works as a translational neuroscientist, directing the Epilepsy Neurophysiology Laboratory; helping lead the multi-departmental study of Cognitive Neurophysiology together with Catherine Schevon MD, Ph.D. and Charles Schroeder, PhD; and collaborating extensively with the Gabriele Bartoli Brain Tumor Research Laboratory. His basic and clinical research has been funded by the National Institutes of Health, the American Association of Neurological Surgeons, the Klingenstein Foundation, the Charles A. Dana Foundation, the New York Academy of Medicine, Parents Against Childhood Epilepsy, the Irving Center for Clinical Research, CURE, and the Tuberous Sclerosis Alliance.
Dr. McKhann graduated Phi Beta Kappa and Magna Cum Laude from Duke University, with Research Honors for his investigations into brain tumor immunobiology. He attended Yale School of Medicine where he was AOA, Cum Laude, a Farr Scholar, and one of five recipients of the medical school’s highest thesis award. Dr. McKhann trained in Neurological Surgery at the University of Washington, as well as Atkinson Morley’s Hospital in Wimbledon, England.
John Mosher, PhD
Professor
McGovern Medical School at the University of Texas Health Science Center
John Mosher, PhD
Professor
McGovern Medical School at the University of Texas Health Science Center
Dr. Mosher is a Professor of Neurology and Scientific Director of Magnetoencephalography Research in the McGovern Medical School at the University of Texas Health Science Center (UTHealth). At UTHealth, he is a member of both the Texas Comprehensive Epilepsy Program and the Texas Institute for Restorative Neurotechnologies. Dr. Mosher is an expert in the field of signal analysis, source modeling and visualization of Magnetoencephalography (MEG) and Electroencephalography data. His main research interests are in developing research and real-time brain imaging tools and translating these into clinical practice.
Dr. Mosher received his Ph.D. degree in Electrical Engineering from the Signal and Image Processing Institute of the University of Southern California. He developed MEG research software programs at the Los Alamos National Laboratory, then later became a Director of MEG Research at the Cleveland Clinic Neurological Institute, before moving to UTHealth. Dr. Mosher has authored nearly 200 papers appearing in Google Scholar, with over 10,000 citations, and he is one of the Principal Investigators of the widely-used software toolbox Brainstorm, which is hosted at USC.
Nigel P. Pedersen, MD
Assistant Professor
Emory University and Georgia Institute of Technology
Nigel P. Pedersen, MD
Assistant Professor
Emory University and Georgia Institute of Technology
Dr. Pedersen graduated with honors from Sydney Medical School in his home country of Australia. He then moved to Beth Israel Deaconess Medical Center in Boston for post-doctoral research training, followed by clinical training in Neurology, Clinical Neurophysiology and Epilepsy, at Harvard Medical School at Beth Israel Deaconess Medical Center, Boston Children’s Hospital and Massachusetts General Hospital. He was briefly on staff at Beth Israel Deaconess Medical Center, before being recruited to develop research in Emory’s Comprehensive Epilepsy Program. Dr. Pedersen is passionate about discovery and innovation in epilepsy and aims to improve the lives of people with epilepsy. He runs a translational basic science and patient-centered research laboratory at Emory University devoted to understanding the systems neuroscience of epilepsy, including how this relates to sleep-wake brain circuits, cortical connectivity and cortical function. His research has been supported by the NIH, CURE Epilepsy, the American Academy of Neurology/American Brain Foundation, and the Woodruff Foundation. Dr. Pedersen’s clinical work is focuses on epilepsy surgery and SEEG.
Dr. Pedersen is the Director of the Epilepsy and Systems Neurobiology Laboratory and part of the Executive Committee for the Emory Graduate Program in Neuroscience.
Jean Regis, MD
Professor
Aix Marseille University.
Jean Regis, MD
Professor
Aix Marseille University
Dr. Regis is Full Professor of Neurosurgery at the Aix Marseille University (Marseille, France), and Neurosurgeon at the Timone University Hospital where he currently serves as Head the Stereotactic, Functional Neurosurgery and Radiosurgery Department. His basic research activity (INSERM UMR 1106) is focused on cerebral cortex gyration modeling and individual brain surgery prediction (The Virtual Brain). His clinical research activity is dedicated to advance imaging applied to surgery and the functional applications of radiosurgery.
Dr. Regis served as Vice President of the European Association of Neurosurgical societies (EANS) 2007 – 2011, Secretary of the European Society for Stereotactic and Functional Neurosurgery (ESSFN) since 2010, President of the International Stereotactic Radiosurgery Society (ISRS) 2011-2013, President of the European Gamma Knife Radiosurgery Society (EGKS) 2011-2015, President of the Société Française de Neurochirurgie (SFNC) 2017- 2019 and Secretary of the Board of Directors of the World Society for Stereotactic and Functional Neurosurgery (WSSFN). He is reviewer for several main international journals.
Hussam Shaker, MD
Clinical Assistant Professor
Mercy health Saint Mary’s, Michigan State University
Hussam Shaker, MD
Clinical Assistant Professor
Mercy health Saint Mary’s, Michigan State University
Dr. Shaker graduated from Tishreen Medical School in Syria and had a research fellowship in Alzheimer’s disease at New York University. He completed his neurology residency at Spectrum Health Hospital and served as a chief resident. After that, he completed a second fellowship in clinical neurophysiology at Cleveland Clinic Foundation. Currently, Dr. Shaker is a clinical assistant professor and Stereotactic electroenecephalogram director at Mercy health Saint Mary’s, Michigan State University.
Stephen Thompson, MD
Assistant Professor
McGovern School of Medicine
Stephen Thompson, MD
Assistant Professor
McGovern School of Medicine
Dr. Thompson is an Assistant Professor of Neurology at the McGovern School of Medicine and Director of the Stereotactic EEG and SEEG Program. He is an expert in the presurgical and invasive evaluation of intractable focal epilepsies, and has special interest in imaging and signal post-processing technologies for epilepsy surgery. He received his medical degree from the University of British Columbia, Vancouver, Canada and did his neurology residency at the Memorial University of Newfoundland. He completed his two-year clinical fellowship in Clinical Neurophysiology, EEG and Epilepsy at the Cleveland Clinic Foundation in Ohio.
Agnes Trebuchon MD, PhD
Neurologist
Aix-Marseille University
Agnes Trebuchon MD, PhD
Neurologist
Aix-Marseille University
Dr. Trebuchon is a Neurologist and Neurophysiologist at Aix-Marseille University / La Timone Hospital in Marseille. She is specialized in intracerebral recordings in patients suffering from pharmacoresistant focal epilepsy candidate to surgical treatment. Her work in the Marseille epilepsy team with Patrick Chauvel and Fabrice Bartolomei started 20 years ago. She always had a clinical interest in ictal semiology involving cognitive aspects with special reference to language, and also her scientific research is principally focused in language mapping using recordings of ERPs, HGF, and electrical intracerebral stimulation.
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